锟斤拷要

锟斤拷锟斤拷锟斤拷一锟絅藥锟斤拷锟叫發(f锟斤拷)锟侥冿拷(y锟斤拷u)锟斤拷(sh锟斤拷)锟角硷拷锟斤拷锟斤拷锟斤拷锟节讹拷N藥锟斤拷暮锟斤拷慕Y(ji锟斤拷)锟斤拷(g锟斤拷u)锟斤拷锟斤拷锟狡學(xu锟斤拷)锟斤拷锟窖岋拷(du锟斤拷)锟斤拷锟組(j锟斤拷n)锟斤拷锟剿廣锟斤拷锟斤拷探锟斤拷锟斤拷锟斤拷锟斤拷一锟絅锟斤拷锟矫碉拷藥效锟斤拷锟紽(tu锟斤拷n)锟斤拷锟斤拷锟斤拷锟斤拷詤f(xi锟斤拷)同锟斤拷锟斤拷(qi锟斤拷ng)藥锟斤拷锟斤拷锟剿幮�锟斤拷锟斤拷锟斤拷w锟斤拷锟斤拷w锟斤拷(n锟斤拷i)锟斤拷锟斤拷W(xu锟斤拷)锟斤拷锟斤拷锟斤拷锟絧小锟紺(j锟斤拷)锟絯锟斤拷锟斤毒锟皆★拷锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷谐锟缴�锟斤拷锟斤拷锟斤拷锟斤拷锟矫讹拷锟斤拷锟斤拷锟矫的組锟斤拷锟斤拷透锟皆猴拷锟斤拷锟斤拷(du锟斤拷)锟絕锟酵的诧拷锟斤拷锟斤拷锟斤拷(y锟斤拷ng)锟斤拷锟斤拷耍锟斤拷锟斤拷锟斤拷呀锟�(j锟斤拷ng)锟缴為當(d锟斤拷ng)锟斤拷藥锟斤拷锟叫發(f锟斤拷)锟絀(l锟斤拷ng)锟斤拷锟斤拷锟斤拷要锟侥骨硷拷之一锟�锟斤拷锟斤拷锟斤拷@一锟斤拷(y锟斤拷u)锟斤拷(sh锟斤拷)锟角硷拷锟斤拷锟叫撅拷锟剿員锟絆(sh锟斤拷)計(j锟斤拷)锟斤拷锟絖锟絣(f锟斤拷)锟剿撅拷锟叫诧拷同藥锟斤拷袠锟�(bi锟斤拷o)锟斤拷锟斤拷锟斤拷藥锟斤拷锟斤拷锟�锟斤拷锟紷些锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟矫碉拷锟斤拷锟斤拷锟斤拷锟�锟斤拷锟界抗锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷(du锟斤拷)锟轿�锟斤拷锟斤拷锟斤拷暮锟侥�锟結锟斤拷锟結(ji锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟酵革拷锟斤拷锟斤拷锟斤拷锟教诧拷锟斤拷锟斤拷锟斤拷锟結锟斤拷锟斤拷锟紽(xi锟斤拷n)锟斤拷锟杰达拷臐锟斤拷锟�锟斤拷

锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷藥锟斤拷锟叫發(f锟斤拷)锟絀(l锟斤拷ng)锟斤拷膽锟�(y锟斤拷ng)锟斤拷

1. 锟斤拷锟斤拷

Zhao锟斤拷锟剿合筹拷锟斤拷一系锟叫碉拷聯(li锟斤拷n)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤（锟紻1锟斤拷锟斤拷锟斤拷锟絬(p锟斤拷ng)锟斤拷锟斤拷锟戒對(du锟斤拷)锟斤拷N锟斤拷锟斤拷锟斤拷w锟解抗锟斤拷锟斤拷锟斤拷锟斤拷锟襟部凤拷聯(li锟斤拷n)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷F(xi锟斤拷n)锟斤拷锟斤拷锟矫的匡拷锟斤拷锟斤拷锟斤拷锟�锟斤拷MIC值锟斤拷锟斤拷0.03125 - 2 锟斤拷g/mL之锟絞锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷1a锟斤拷(du锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷@锟斤拷锟斤拷锟斤拷锟狡伙拷锟斤拷锟斤拷锟斤拷MIC值锟斤拷(y锟斤拷u)锟斤拷某些锟斤拷锟叫匡拷锟斤拷藥锟斤拷锟斤拷锟斤拷锟解，锟斤拷锟斤拷锟斤拷1a锟斤拷1b锟斤拷(du锟斤拷)A549锟斤拷(x锟斤拷)锟斤拷锟斤拷锟剿凤拷小锟斤拷(x锟斤拷)锟斤拷锟轿帮拷锟斤拷(x锟斤拷)锟斤拷锟斤拷锟斤拷U87锟斤拷(x锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷(j锟斤拷ng)锟絲锟絴(zh锟斤拷)锟斤拷锟斤拷(x锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟矫碉拷锟斤拷锟斤拷锟斤拷锟斤拷锟皆ｏ拷IC50 锟斤拷 50 锟斤拷M锟斤拷锟斤拷锟斤拷SAR锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷聯(li锟斤拷n)锟斤拷锟斤拷锟斤拷位锟斤拷锟絞位锟较达拷锟斤拷锟斤拷锟斤拷踊锟斤拷F(tu锟斤拷n)锟斤拷锟斤拷锟斤拷F锟斤拷Cl锟斤拷CN锟斤拷取锟斤拷锟絩(sh锟斤拷)锟斤拷锟饺岋拷(d锟斤拷o)锟斤拷锟斤拷锟斤拷目锟斤拷锟斤拷锟斤拷锟斤拷锟紷锟斤拷锟斤拷锟斤拷(qi锟斤拷ng)锟斤拷

2. 锟斤拷锟斤拷锟斤拷锟絰

锟斤拷探锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤對(du锟斤拷)锟斤拷同锟斤拷锟斤拷锟絰锟斤拷锟斤拷锟狡伙拷锟斤拷锟斤拷 Saccoliti锟斤拷锟斤拷锟絆(sh锟斤拷)計(j锟斤拷)锟斤拷锟较筹拷锟斤拷一系锟斤拷锟斤拷锟斤拷-锟斤拷锟斤拷锟斤拷锟斤拷锟斤。锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷2a锟斤拷锟絕锟矫碉拷锟斤拷锟狡匡拷锟斤拷锟紽锟絰锟斤拷T. cruzi锟斤拷锟斤拷锟斤拷殖锟斤拷锟皆ｏ拷IC50 = 2 nM锟斤拷锟斤拷锟斤拷IC50值锟絟(yu锟斤拷n)锟斤拷锟节岋拷(du锟斤拷)锟斤拷藥锟斤拷M锟斤拷IC50 = 1.65 锟斤拷M锟斤拷锟斤拷锟揭撅拷锟斤拷锟絕锟竭碉拷锟斤拷锟斤拷锟斤拷锟斤拷锟皆ｏ拷SI = 85 - 2615锟斤拷锟斤拷锟叫橈拷(bi锟斤拷o)锟斤拷锟紸(ch锟斤拷)锟叫撅拷锟斤拷锟斤拷2a锟斤拷(du锟斤拷)酶CYP51锟侥結(ji锟斤拷)锟斤拷锟紿锟斤拷锟斤拷锟絕锟竭ｏ拷< 25 nM锟斤拷锟斤拷锟絯锟斤拷(n锟斤拷i)锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷2a锟斤拷25 mg/kg锟絩(sh锟斤拷)锟斤拷锟斤拷锟斤拷98.5锟斤拷锟侥硷拷锟斤拷锟絰锟斤拷锟斤拷锟給锟轿何硷拷锟皆讹拷锟斤拷锟紼锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷2b锟斤拷2c锟斤拷锟斤拷效锟斤拷锟界惡锟皆�锟皆�锟絰锟斤拷IC50 = 0.13 - 0.14 锟斤拷M锟斤拷锟斤拷

3. 锟斤拷锟斤拷锟斤拷

Hu锟斤拷锟斤拷通锟絕锟斤拷變锟紹锟斤拷锟斤拷锟斤拷羌锟街�锟斤拷鏈碉拷锟絃(zh锟斤拷ng)锟斤拷锟斤拷锟絆(sh锟斤拷)計(j锟斤拷)锟较筹拷锟斤拷一系锟斤拷锟斤拷锟斤拷锟姐豆锟斤拷锟斤拷锟斤拷锟斤（锟紻3锟斤拷锟斤拷锟斤拷锟斤拷(du锟斤拷)锟戒抗IHNV锟斤拷锟斤拷染锟斤拷锟斤拷血锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟組(j锟斤拷n)锟斤拷锟剿篩锟絰锟斤拷锟絯锟斤拷y(c锟斤拷)锟斤拷锟結(ji锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷該系锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷十锟斤拷锟絅锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟紷锟斤拷锟狡筹拷锟絕锟诫數(sh锟斤拷)IHNV锟角碉拷锟阶的產(ch锟斤拷n)锟斤拷锟斤拷锟斤拷锟絅锟斤拷锟斤拷锟斤拷锟斤拷10 锟斤拷M锟絩(sh锟斤拷)锟斤拷锟斤拷锟斤拷效锟斤拷锟斤拷IHNV锟角碉拷锟阶產(ch锟斤拷n)锟斤拷锟斤拷锟斤拷锟紷些锟斤拷锟皆伙拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷3a锟斤拷锟紷锟斤拷锟斤拷锟斤拷IHNV锟斤拷锟皆ｏ拷IC50 = 2.53 锟斤拷M, CC50 = 17.13 锟斤拷M锟斤拷锟斤拷锟斤拷(x锟斤拷)锟斤拷锟斤拷變效锟斤拷(y锟斤拷ng)锟斤拷CPE锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷3a锟斤拷(du锟斤拷)锟斤拷染IHNV锟斤拷锟斤拷募锟�(x锟斤拷)锟斤拷锟斤拷變锟斤拷锟斤拷锟斤拷锟紷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟解，锟节斤拷(j锟斤拷ng)锟斤拷锟斤拷锟斤拷3a處锟斤拷锟斤拷血锟杰冿拷(n锟斤拷i)皮锟芥細(x锟斤拷)锟斤拷锟斤拷EPC锟斤拷锟斤拷锟絕锟届到锟斤拷锟戒對(du锟斤拷)IHNV锟斤拷锟斤拷效锟斤拷锟斤拷锟斤拷锟紺锟斤拷(sh锟斤拷)锟剿伙拷锟斤拷锟斤拷3a锟斤拷锟斤拷锟斤拷IHNV锟斤拷EPC锟斤拷(x锟斤拷)锟斤拷锟叫的忥拷(f锟斤拷)锟斤拷锟斤拷

4. 锟斤拷锟斤拷锟斤拷

Adib锟斤拷锟剿合筹拷锟斤拷一系锟斤拷锟斤拷锟斤拷锟侥氾拷锟斤拷锟斤拷锟斤拷锟较碉拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤（锟紻4锟斤拷锟斤拷锟斤拷锟絬(p锟斤拷ng)锟斤拷锟斤拷锟斤拷锟絯锟斤拷锟�-锟斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷锟狡伙拷锟斤拷锟斤拷锟結(ji锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫伙拷锟斤拷锟斤拷锟斤拷锟斤拷F(xi锟斤拷n)锟斤拷锟斤拷锟矫碉拷锟絯锟斤拷锟�-锟斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷锟狡伙拷锟皆ｏ拷IC50 = 74.0 - 298.3 锟斤拷M锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷4a锟斤拷4b锟斤拷(du锟斤拷)锟斤拷-锟斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷锟斤拷锟斤拷效锟斤拷锟斤拷锟斤拷锟斤拷@锟斤拷IC50值锟街別锟斤拷74.0锟斤拷81.0 锟斤拷M锟斤拷锟斤拷锟斤拷锟接岋拷(du锟斤拷)锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷4a锟斤拷4b锟斤拷锟絚锟斤拷-锟斤拷锟斤拷锟斤拷锟斤拷酶锟侥伙拷锟斤拷位锟絚(di锟斤拷n)锟斤拷Y(ji锟斤拷)锟斤拷锟斤拷锟斤拷锟解，SAR锟叫撅拷锟斤拷锟斤拷锟斤拷锟节憋拷锟絟(hu锟斤拷n)锟斤拷(du锟斤拷)位锟斤拷锟斤拷锟斤拷锟斤拷诮o锟斤拷踊锟斤拷F(tu锟斤拷n)锟斤拷锟斤拷锟絞位锟斤拷锟絕小锟斤拷锟斤拷锟斤拷踊锟斤拷F(tu锟斤拷n)锟斤拷锟斤拷锟斤拷锟絬锟截ｏ拷取锟斤拷锟杰產(ch锟斤拷n)锟斤拷锟斤拷锟矫碉拷锟斤拷锟斤拷效锟斤拷锟斤拷

5. 锟斤拷锟斤拷

Dianat锟斤拷锟剿伙拷锟斤拷2-锟斤拷锟斤拷锟斤拷O(sh锟斤拷)計(j锟斤拷)锟斤拷锟较筹拷锟斤拷一系锟叫庯拷锟叫达拷位锟斤拷锟斤拷锟斤拷锟斤拷锟�(c锟斤拷)鏈碉拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤（锟紻5锟斤拷锟斤拷锟絯锟斤拷15-LOX锟斤拷15-脂锟斤拷锟斤拷酶锟斤拷锟阶ｏ拷锟斤拷锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷該系锟叫伙拷锟斤拷锟斤拷锟斤拷锟斤拷F(xi锟斤拷n)锟斤拷锟斤拷锟斤拷锟矫碉拷锟斤拷锟斤拷效锟斤拷锟斤拷IC50 < 40 锟斤拷M锟斤拷锟斤拷锟絚锟斤拷(du锟斤拷)锟斤拷藥锟斤拷锟斤拷锟�锟斤拷锟斤拷锟斤拷锟斤拷5b锟斤拷锟紽(xi锟斤拷n)锟斤拷锟斤拷锟竭碉拷15-LOX锟斤拷锟狡伙拷锟皆ｏ拷IC50 = 11.5 锟斤拷M锟斤拷锟斤拷锟斤拷锟解，锟斤拷锟斤拷锟斤拷5b锟絚15-LOX酶锟斤拷锟斤拷位锟絚(di锟斤拷n)锟斤拷(du锟斤拷)锟斤拷锟叫撅拷锟侥結(ji锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷5b锟結(ji锟斤拷)锟斤拷(g锟斤拷u)锟斤拷2-锟斤拷锟斤拷锟斤拷锟斤拷值谋锟斤拷h(hu锟斤拷n)锟絚15-LOX锟斤拷锟斤拷位锟絚(di锟斤拷n)锟斤拷Fe3+锟絰锟斤拷之锟絞锟斤拷锟斤拷锟斤拷x锟斤拷-锟斤拷锟洁互锟斤拷锟矫ｏ拷同锟絩(sh锟斤拷)該锟結(ji锟斤拷)锟斤拷(g锟斤拷u)锟叫碉拷锟藉丁锟斤拷锟斤拷锟斤拷還锟斤拷锟絚15-LOX锟斤拷水锟节达拷锟侥革拷锟絅锟斤拷锟斤拷锟絘(ch锟斤拷n)锟斤拷锟斤拷水锟斤拷锟洁互锟斤拷锟矫ｏ拷锟斤拷锟組(j锟斤拷n)锟剿伙拷锟斤拷锟斤拷5b锟絚15-LOX锟斤拷锟斤拷效锟結(ji锟斤拷)锟斤拷锟斤拷锟組(j锟斤拷n)锟斤拷锟斤拷锟斤拷15-LOX锟侥伙拷锟斤拷锟斤拷

6. 锟斤拷锟斤拷锟斤拷锟侥猴拷默锟結

锟斤拷锟斤拷探锟斤拷锟轿伙拷锟絧取锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤對(du锟斤拷)锟斤拷锟斤拷膽锟紸锟斤拷酶锟斤拷AChE锟斤拷锟酵讹拷锟斤拷膽锟紸锟斤拷酶锟斤拷BChE锟斤拷锟斤拷锟斤拷锟狡伙拷锟斤拷锟斤拷Kuzu锟斤拷锟斤拷锟斤拷锟斤拷一系锟叫碉拷锟叫撅拷锟斤拷锟紻6锟斤拷锟斤拷锟結(ji锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷锟紷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟缴岋拷(du锟斤拷)AChE锟斤拷IC50 = 17.3 - 120.9 nM锟斤拷锟斤拷BChE锟斤拷IC50 = 27.02 - 151.2 nM锟斤拷锟絘(ch锟斤拷n)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷藥效锟斤拷锟絖(d锟斤拷)锟斤拷(bi锟斤拷o)锟斤拷(zh锟斤拷n)藥锟斤拷锟�20 - 40锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷6a锟斤拷锟斤拷-锟斤拷锟斤拷取锟斤拷锟斤拷锟斤拷(du锟斤拷)锟缴種锟斤拷酶锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟筋強(qi锟斤拷ng)锟斤拷IC50值锟街別锟斤拷17.3锟斤拷27.02 nM锟斤拷3,4-锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷取锟斤拷锟斤拷6b锟斤拷2-锟脚伙拷取锟斤拷锟斤拷6c锟斤拷锟斤拷锟紷锟斤拷锟斤拷AChE锟斤拷BChE锟斤拷锟狡伙拷锟皆ｏ拷锟斤拷(du锟斤拷)锟斤拷AChE锟斤拷IC50值锟街別锟斤拷17.3锟斤拷17.32 nM锟斤拷锟斤拷锟斤拷(du锟斤拷)锟斤拷BChE锟斤拷锟斤拷锟斤拷锟斤拷IC50值锟絫锟街別锟斤拷41.67锟斤拷64.28 nM锟斤拷SAR锟叫撅拷锟斤拷锟斤拷锟斤拷取锟斤拷锟斤拷锟斤拷锟斤拷锟絴(zh锟斤拷)锟斤拷锟斤拷锟节凤拷锟絟(hu锟斤拷n)锟较碉拷锟斤拷锟斤拷(du锟斤拷)位锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷W(xu锟斤拷)锟斤拷锟皆碉拷锟斤拷要影锟斤拷锟斤拷亍锟斤拷锟斤拷锟斤拷訉锟�(du锟斤拷)锟斤拷锟叫撅拷锟紷示锟斤拷锟斤拷锟斤拷AChE锟斤拷要锟斤拷锟斤拷位锟絚(di锟斤拷n)锟侥革拷锟絅锟斤拷锟斤拷锟结殘锟斤拷锟絚藥锟斤拷锟斤拷锟街�锟絞锟斤拷锟洁互锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷c之锟絘(ch锟斤拷n)锟斤拷锟截�锟斤拷越Y(ji锟斤拷)锟较★拷

锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷藥锟叫發(f锟斤拷)锟絀(l锟斤拷ng)锟斤拷锟斤拷锟斤拷锟揭�锟侥碉拷位锟斤拷目前锟斤拷锟叫讹拷N锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟組(j锟斤拷n)锟斤拷锟絉锟斤拷锟叫發(f锟斤拷)锟紸锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷途锟絍锟斤拷锟侥冿拷(y锟斤拷u)锟斤拷(sh锟斤拷)锟角硷拷之一锟斤拷锟叫撅拷锟剿員锟窖合成诧拷锟結锟絰锟剿讹拷N锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷一些锟斤拷锟叫筹拷色锟斤拷藥锟斤拷锟斤拷浴锟�

锟斤拷锟斤拷锟侥獻(xi锟斤拷n)

[1] An insight into the medicinal perspective of synthetic analogs of imidazole, Sandeep Rulhania, Shubham Kumar, Bhupender Nehra, GD Gupta, and Vikramdeep Monga*, J_Mol_Struct,2021, 1232, Doi: 10.1016/j.molstruc.129982.